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This book presents a multidisciplinary evidence-based approach to the management of teeth with lesions of endodontic-periodontal origin. It addresses the etiology and classification of these lesions while demonstrating their relevance to daily clinical practice. The text covers modern procedures in periodontal regeneration, vertical root fracture management, and treatment alternatives following tooth extraction. It also integrates clinical factors and patient values into comprehensive treatment planning, making it an essential resource for dental professionals.