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This comprehensive clinical guide details the etiology, pathogenesis, and management of peri-implant infections through a modular treatment approach. It covers diagnostic methods including radiologic and microbiologic procedures alongside nonsurgical therapies like laser decontamination and antimicrobial treatments. The text provides in-depth analysis of surgical resective and regenerative procedures supported by numerous clinical case studies. Expert contributions clarify peri-implant tissue anatomy to ensure long-term prognosis for implant retention in modern dental practice.